It's possible, but difficult. You'll need a 55-up V8 bellhousing and a 54 truck middle crossmember. The torque tube length might be right, as the fore/aft position of the transmission won't change much, if any. The engine will be wound up pretty tight at highway speed due to the 4.10 rear end gear, but it won't hurt a small block V8 to run that speed. Wear earplugs!
Jerry