In your opinion what would be the best way to get this out?
You have a
lot of work to do on that fender, but fortunately you don't have any sharp lines/creases plus it can be made to look about like new with careful work. And no matter what anyone might tell you, there are different ways to fix it. Please remember metal has a memory. I realize that might sound odd, but it is true. If it were me, I'd remove the fender and sand all the paint off around the damaged areas and remove any dirt, etc on the back side. Then get a pick/finishing hammer and either a general use dolly or a hand held 8 pound hammer with one face made smooth. I would start working very carefully at the edges heading in to the center of the damage. Begin with the dent that is midway on your fender...the one above your hub. That will be the easiest one (obviously). When you get the feel for how the metal will work, then move to the front dent.
Just remember to take your time and don't start in the center of any damage. I'm not a big fan of slide hammer work, but some people like it. If you need to shrink metal (and in this case you probably will), then you can use the pick part of the hammer and a sandbag or a soft pine board. I try to do that as little as possible, however. I'm a fan of getting the metal as close to original as possible before using any filler. Look on Google. You will probably find many ideas on straightening metal and maybe even some tutorials. I wouldn't waste my time with YouTube, but that's just me. Once you get started feel free to reach out to the folks here. Good luck.