I don't see anything wrong with it. Is it a 5 lug or 8 lug version on the 9.25? I had an 82 B250 that was 5 lug. I know there was a 8 lug version in some later models.
The 9.25 is a semi-float axle, wheras the HO52 is a full float axle, meaning all the weight is held on the hub and wheel bearing and not the axle shaft. In terms of shear strength, the full float axle will win hands down, but realistically I don't see anyone ever loading a 70 year truck heavy enough to find out where the breaking point of it's axle is.