It sounds like you are looking for almost the same thing from your truck as I am from the truck I am building. The only possible difference being the load you want to carry. I will be able to carry about 8,000 lb and tow more than that. What are your plans, to carry a load occasionally, and how much, or to use the truck like a car?
For my approach (48 Chevy 2 ton 6400) I thought that the stock frame was adequate, and will allow a much cleaner job than swapping for a later model frame.
For the brakes I swapped later model axles with large disc brakes up to the task of stopping the load I want to carry.
I used the original suspension design, but with new springs, and I will add air springs front and rear that I can adjust to the load at hand.
I also added power steering and a hydrobooster for the brakes.
All of this with the original frame that nicely fits the body it came under. I think that my modifications for the most part look as if the truck came that way stock, as I like this look and the simplicity. I think this look can only easily come from using the stock frame and body.
My truck will also have AC, a radio, cruse control, and many other modern things.
I have driven my 1 ton with the very same axle, brake, and steering modifications that are now on my 2 ton project, and I liked the way it drove and handled. I see no need for a different frame or front clip for my needs.
If you want a frame swap because that's what you want, then go for it, we'll help along the way.
Along similar lines I choose a diesel engine for mine because that's what I want, right or wrong, it is in my truck. If you want a frame swap just because you do then there is nothing wrong with that, it's your truck.
Lets hear some more of what you want your truck to do and how it should perform. Are you set on a frame swap, or open to other ideas if they make the truck what you want in the end?
Grigg