It will work. I did it on a 216 in a 51 chevy 2dr sdn. I didn't notice a big issue. My original carb was leaking so bad I thought was going to catch fire. I had another carb off of a 235 Babbitt in a 51 also but the base was different. That's why I swapped. I ran that carb till the clutch went 2 yrs later. Then it was time for the 261 I had waiting for it.