Original (or similar) engine and transmission? I'd put them right back where they came from, keep it simple.

Non original engine? Would moving it to the side a little help some other aspect of the install or make it more difficult? Either way is fine, but don't make unnecessary work for yourself.

•1951 GMC 250 in the Project Journals
•1948 Chevrolet 6400 - Detroit Diesel 4-53T - Roadranger 10 speed overdrive - 4 wheel disc brakes
•1952 Chevrolet 3800 pickup
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"First, get a clear notion of what you desire to accomplish, and then in all probability you will succeed in doing it..." -Henry Maudslay-