Often, more fuel economy may be gained AWAY from the engine:
http://www.thecarburetorshop.com/Troubleshooting.htm#FueleconomyThe two largest fuel mileage increases I acquired on my current shop truck were: (1) replace the dogmatic transmission with manual - 26 %, and (2) remove the bug screen - 21 %.
Changing from a Holley 2-barrel to a Carter 4-barrel picked up about 15 percent, and replacing the Carter 4-barrel with TWO Carter 4-barrels another 6 percent. (No, it isn't a stovebolt 6).
Jon