All tests that I have seen dropping the tailgate hurt the mileage.
On the other hand, a cab-high aluminum bed topper seems to help the mileage.
Personally, the two largest gains I made on my own 1968:
(1) Switch from a dogmatic to a 4-speed (24 percent)
(2) Removal of the "bug screen along the front of the hood (12 percent)
Jon