The only advantage I can imagine would be that a single 2 barrel would be head and shoulders above the same amount of venturi area split between two carbs like the Fenton manifold, etc. A 2-into-1 arrangement like there would be with an adapter on a regular 1 barrel manifold has been proved many times to get worse performance than the 1 barrel it replaces. If someone were to machine or cast a manifold with a properly shaped plenum to accommodate a SMALL 2-barrel like the Stromberg 97 that fit the 239 cubic inch flathead Ford might be worth considering.
Jerry

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