I have a 46 2-ton with the original (rebuilt) 235. Still has the babbit splash lubricated rods in it. Nothing special inside. .020 or .030 over, can't remember. 8.25 tires on the rear. Stock carb and exhaust manifold. I think the exhaust pipe is 2" or 2 1/4". I made it out of stainless and can't remember what I used. Still has stock points and I run a Bosch blue coil like you would see on a mid 60's VW beetle.
I can run on the interstate at 50-55 easily. 60 starts to feel a little uncomfortable after a little while. I have had my GPS show over 60 before. Not something I would want to do for hours, but I have done the 50-55 for a hundred+ mile trip before.
I also have disc brakes on the front, so stopping isn't an issue. Steering on the other hand... I had an employee pull in a parking lot with 12,000 on the back and he came back out to a broken steering shaft. Couldn't have happened at any other time and have a good ending. I pulled another steering box apart and had the shaft magna fluxed before putting it back together, just to make sure!
Make sure everything is in order. Ignition, charging system, brakes, etc.
