Off the top of my head you will have to make mounts,cut off the ends of frame , and on a 46 possibly rework the frame where it kicks out behind the front wheels ? Or it might just be a matter of a little trimming on the body. Also move the engine and trans mounts back a few inches. I was using a different body style you would have to mock it up and see what needs to be done. Nothing a little time and a welder can't fix.
Long bed regular cab works well with no mods on a short bed.
If you did have to change the wheelbase the S10 frame splits in the middle cut some welds cut it to shorten or extend length and re-weld.