Hi Andy, welcome to the site! Not everyone pokes around here in the welcome forum so, your question may get more attention in the appropriate forum, (driveline, or maybe the hi-po forum since you are asking about a complete different frame than original). One of the first question back at you will be, what do you want to do with your truck? If you want to putter around on the farm, it would be a completely different build than making a streetrod to go fast just on the weekends, and something even different yet if you want something to drive daily cruising down the interstate at 90 mph. From your comment about an S-10 frame, it sounds like you don't care about keeping the original drivetrain and want something more modern under your old sheet metal, is that correct?