If you want to put a different axle in it you can do just about anything you want. I would imagine that there would be a lot more aftermarket parts available for the Dana 80 than the S110 - more gear ratios to choose from, etc.

You have to be careful though - if you're still running the original style stovebolt engine then gearing it up too much is really going to hurt the drivability. It won't have enough power to pull a tall gear.

I put a 5.43 in my '50 behind the original 235 and it pulls it just fine and allows me to go 55-60 - which is about as fast as I'd ever want to go in that truck anyway. I doubt it would pull well with a gear much taller than that though.

1950 4100 - unrestored and driven weekly for almost no reason at all.