I know people with ceramic coating on 6 cylinder manifolds, professionally installed by companies that specialize in coating exhaust manifolds. Those have held up quite well over several years and many miles (including cross-country trips).

I have never tried ceramic, but I have tried high-heat manifold paint, with no good luck. I now use the Calyx Manifold Dressing mentioned by Lonnie in a previous post. It needs an easy 5-10 minute "touch up" every year.