There will probably be the same steering gear clearance issues as with a V8. The 4.3 is basically a 305 with two cylinders lopped off the front. Since you're using aftermarket front suspension, that might not be a serious problem. If you run a 700R4 instead of a 350 you'll have overdrive. Lots of S-10 pickups ran the 4.3/700R4 combination so an engine/trans assembly shouldn't be hard to find.
Jerry

"It is better to be silent and be thought a fool than to speak and eliminate all doubt!" - Abraham Lincoln
Cringe and wail in fear, Eloi- - - - -we Morlocks are on the hunt!
There is nothing noble in being superior to your fellow man; true nobility is being superior to your former self. - Ernest Hemingway
Love your enemies and drive 'em nuts!