That's actually incorrect. The S10 suspension is based on the '78-'88 GM A and G body metric Passenger car suspension on the 2wds, and the Oldsmobile Toronado/Cadillac Eldorado/Buick Riviera suspensions for the 4wd. In either case, adding spacer WILL alter the alignment specs, including several dimensions that have no factory adjustment, as they are designed into the spindle itself.
Enlighten us which dimensions have no factory adjustment on an S-10 that would be affected by spacers?